What “Calories In, Calories Out” (CICO) Is Simply, CICO says that gaining or losing weight is based on how many calories you consume (what you eat and drink) and how many calories you burn. If you burn more than you consume, you will lose weight; if you consume more than you burn, you will gain weight. “Calories Out” encompasses: CICO is governed by the laws of thermodynamics: when energy (calories) is surplus and is being spent, the body stores it; … Continue reading The New Science Behind Calories In, Calories Out for Weight Control