Best Cancer Treatment Centers in the USA for 2025

Once again, cancer hospitals are honored to be ranked by U.S. News & World Report on its Best Hospital list, with the University of Texas MD Anderson Cancer Center and the Memorial Sloan Kettering Cancer Center.

• The five top hospitals for cancer, according to the 2025 to 2026 ranking, follow:
• University of Texas MD Anderson Cancer Center (Houston, TX)
• Memorial Sloan Kettering (MSK) Cancer Center (New York, NY)
• Dana-Farber Brigham Cancer Center (Boston, MA)
• Mayo Clinic-Rochester (Rochester, MN)
• Massachusetts General Hospital (Boston, MA)

“e; In an official press release, MD Anderson President Peter WT Pisters, MD, said, ‘We are honored again to be ranked as the nation’s top hospital for cancer care, a reaffirmation of our commitment to a shared mission to end cancer.’ Thanks are extended to every one of our teammates, trainees, students, donors, volunteers, advocates, and patients whose loyal devotion makes it possible for MD Anderson to provide such extraordinary patient care.”

Memorial Sloan Kettering fell into second place as it did last year and still dominates a list that skews heavily toward northeastern centers. “This recognition reminds us of MSK’s unique role in the history and future of cancer care and the obligation we have to patients,” Dr. Selwyn M. Vickers, president and CEO of Memorial Sloan Kettering, said.

Massachusetts General Hospital in Boston made the biggest jump from number 11 last year to number 5 within this year’s ranking. “We are thrilled that Mass General Brigham has been recognized by U.S. News & World Report for our excellence in cancer care,” stated President David Ryan, MD. “Our two founding member organizations-Massachusetts General Hospital and Brigham and Women’s Hospital-have both been ranked among the top five cancer hospitals in the country, reflecting our sustained progress improving outcomes through our unified quality strategy: For Every Patient.”

“Our outstanding clinicians and care teams are working together, advancing proven initiatives that help us improve the lives of our patients and improve our inpatient mortality. As we bring together our world-class experts under a single Mass General Brigham Cancer Institute, we will continue this focus on excellent patient outcomes and groundbreaking, research-infused care,” further added Dr. Ryan.

Mayo Clinic and Dana-Farber Brigham Cancer Center have changed places. Since the rankings were released for the 2015-16 period, the University of Texas MD Anderson Cancer Center has always been at the top and has continued to be at least one of the top two since the survey started in 1990.

This marks the 36th annual list compiled by U.S. News, which reviews almost 5000 hospitals and surveys 30,000 physicians for its rankings. As far as specialties, including cancers, are concerned, only 160 out of such institutions received the stamp of approval of being rated based on at least one specialty. Ratings are mostly dependent on outcomes of patients, safety standards, staffing methods, and the reputation of physicians.

The rankings for overall cancer hospitals were fairly minimal in reform by U.S. News this year. However, it underwent an overall new design regarding ratings for cancer-specific procedures and conditions. The more crucial change, as pointed out by U.S. News managing editor and chief health analyst Ben Harder, would be how the publication will rank hospitals for concern related to individual cancers such as colon cancer, lung cancer, leukemia and lymphoma treatment, gynecologic cancer surgery, and prostate cancer.

“This year’s methodology is far more outcome-oriented,” he told Oncology News Central. More so, as much as 60% to 70% of the score that is assigned to each hospital in those specific categories is based on risk-adjusted outcomes.”

Harder went on to claim that the drug shortages that occurred while hospitals were being assessed would not completely alter rankings. We didn’t see any dramatic changes in outcome rates, he said.

The Journey of Cancer Treatment Began with Choosing a Hospital That Is Well-versed in Oncology:
Consideration Gigs for Best Cancer Hospitals in the US 2025

1. Memorial Sloan Kettering Cancer Center: New York

Located in Manhattan, MSK or MSKCC has a long-time reputation as an innovator in the fields of cancer research and treatment. More than 140 years in existence, it is still at the cutting edge of immunotherapy and genetic cancer profiling. An estimated 1,700 medical residents and Fellows-in-training are on campus at MSK.

Key Features:

• Advanced genetic testing
• Updated target therapies
• World’s best surgical oncology teams. Explore more https://health.usnews.com/best-hospitals/rankings/cancer
• Collaborative pediatric and adult oncology services

2. Mayo Clinic – Rochester, Minnesota

Although known for excellence in numerous specialties, the Mayo Clinic demonstrates to other countries that it is the best cancer center in 2025. Mayo Clinic has been working with patients under an integrative, patient-first model that guarantees that patients receive multidisciplinary care in one location for over 139 years. In 2022, for more than 1.3 million different patients from all states across the United States and 100+ countries, consultations took place within Mayo Clinic facilities.

Key Features:

• Highly personalized care plans
• Individualized Medicine Program
• Integration of supportive services (nutrition, psychology)
• High Survival and Recovery Rates
• Access to novel therapies through Mayo Clinic Cancer Center. Explore more https://en.wikipedia.org/wiki/Mayo_Clinic

3. Dana-Farber Cancer Institute – Boston, Massachusetts

It was established by Sidney Farber, MD. It has been affiliated with Harvard Medical School. Dana-Farber remains at the forefront of cancer research and education. With over 77 years of experience, it is particularly renowned for its pediatric and hematologic cancer programs.

Key Features:

• Harvard-affiliated clinical research and trials
• Application of Latest Clinical Research
• Enormous Emphasis on Pediatric Oncology
• Multidisciplinary Care Teams
• Collaboration with Brigham and Women’s Hospital for surgery and radiology

4. Cleveland Clinic – Cleveland, Ohio

Founded in 1921, thus 104 years old by 2025. The Cleveland Clinic’s Taussig Cancer Institute ranks among the best cancer hospitals in the USA 2025 because of its innovative treatment schemes, particularly in lung and colorectal cancers.

Key Features:

• Laney ranked for lung cancer care
• Taussig Cancer Institute
• Robust use of AI for diagnostics
• Best Pioneering Research and Clinical Trials

5. Johns Hopkins Cancer Hospital – Baltimore, Maryland

Established in 1889. Johns Hopkins continues to play a vital role in cancer innovation, with programs specifically strong in the areas of pancreatic and brain cancers. The cancer hospital is ranked to be the best in the United States for the treatment of cancer patients.

Key Features:

• Strong neuro-oncology department
• World’s best Research and Innovation
• Pioneers in cancer vaccine research
• Expertise in Complex and Rare Cancers
• State-of-the-art proton therapy center

6. Seattle Cancer Care Alliance – Seattle, Washington

The Seattle Cancer Care Alliance – Seattle, Washington: Established in 1975, this alliance between Fred Hutchinson Cancer Research Center, UW Medicine, and Seattle Children’s is a world-class cancer care provider with a research-backed approach. The center has three Nobel Prize recipients in physiology and medicine among its employees.

Key Features:

• Directed cancer care and navigation services
• Powerful Collaboration of Leading Institutions
• Leader in CAR T-Cell Therapy
• NCI Designation

7. NYU Langone’s Perlmutter Cancer Centre-New York

Perlmutter Cancer Center is improving fast within the rankings. It is known for individual cancer therapies and taking a real concern about the patients’ wellness.

Key Features:

• Integrative medicine offerings
• Strong outcomes for bladder and kidney cancers
• Robust community outreach programs

8. Northwestern Memorial Hospital-Chicago, Illinois

Home to the Robert H. Lurie Comprehensive Cancer Center. Following a reputation in acute research and personal medicine, Northwestern is gaining fame in this area.

Main Features:

• Complete care coordination
• Strong clinical trial involvement
• Multidisciplinary teams under one roof

How to Choose the Right Cancer Hospital?

While these institutions are often amongst the best, the “right” hospital may depend on several factors of a personal nature:

Type and Stage of Cancer
Many hospitals may specialize in certain types of cancer, such as brain, breast, or pediatric cancers, etc. Make sure the center has good experience with your specific diagnosis.

Access to Clinical Trials
For those with advanced or rare cancers, participating in clinical trials could be vital. Best hospitals often offer access to the latest experimental treatments.

Insurance Coverage
Not all elite centers are covered under every insurance plan. Verify in-network hospitals to manage treatment costs.

Final Thoughts:

Selecting the best cancer hospital can change one’s life. The best cancer centers in the US for 2025 will be setting new standards with contemporary oncological research, compassionate care with dedicated patients, and personal avenues of treatment. Be it standard chemotherapy, immunotherapy, or something more experimental with clinical trials, these facilities on the list would probably provide the best options in the world.

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